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hepatica ES products identified a single protein (FhHDM-1), which mimicked the protective effect of the ES products in preventing both insulitis and hyperglycemia in the non-obese diabetic (NOD) mouse model of T1D (104)
The paper established MOTS-c as an "exercise mimetic" and launched the field of mitochondrial-derived peptide research (Lee C et al., Cell Metab
For example: Endogenous GHRH has a half-life of ~515 minutes Native GLP-1 is broken down in under 2 minutes Thats why natural peptides are rarely used directly in therapeutics theyre too unstable
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